Dezvoltarea platformelor de cercetare INOVABIOMED și GRABTOP a permis menținerea și extinderea colaborărilor naționale și internaționale, fapt reflectat și în rezultatele cercetării așa cum rezultă din proiectele de cercetare și activitatea de diseminare prin publicare, desfășurate în perioada 2017-2022.

 

  • Proiecte câștigate:
  1. Biosenzor inovativ pe bază de grafenă ȋn vederea testării potențialului osteogenic; ȋnțelegerea avansată a performanțelor celulelor stem pentru medicină regenerativă (ID: 320163003) Program Operational Competitivitate (POC) / Acţiunea 1.1.4 Atragerea de personal cu competențe avansate din străinătate pentru consolidarea capacităţii CD, 25 Noiembrie 2016 – 25 Noiembrie 2022, Director Prof. Dr. Ing. Mariana I IONIȚĂ

 

  1. Materiale supercarbonice pentru separare selectivă; proiectare asistata de calculator la multiscala si experimente (ID: 22018192), Planul national, PN III (2013-2020) / Proiecte de cercetare pentru stimularea tinerelor echipe independente (TE), 1 Ianuarie 2018 — 30 Noiembrie 2020, Director Prof. Dr. Ing. Mariana I IONITA

 

  1. Kit pentru regenerare osoasă personalizată; o strategie pentru viitor, REOSTEOKIT (ID: 22022821), Planul national, PN III (2013-2020) / PCE 2020, 2 Iunie 2022 — 31 Decembrie 2024, Director Prof. Dr. Ing. Mariana I IONITA

 

  1. Mixed Reality e-learning platform dedicated to Medical Engineering, REALME (ID: 120224465), Granturi SEE și Norvegiene / SEE 2014-2020, 1 Mai 2022 — 30 Septembrie 2023, Director Prof. Dr. Ing. Mariana I IONITA

 

  1. Proiect privind învățământul secundar (Rose) Schema de granturi pentru Universități, Dezvoltarea competențelor în domeniul Inginerie Medicală – DCMed, 2019-2021, Director grant SL. Dr. ing. Andreia Cucuruz

 

  1. Model in-vitro de stimulare a recuperării osoase folosind stimuli mecanici, Granturi Naționale, GNAC ARUT octombrie 2018-decembrie 2019, 45.000 lei, director proiect –SL Dr. Biol. Adela Banciu

 

  1. Radioterapie Adaptiva (AdaptRT), Proiect GeX, Perioada: 12 luni 2017- 2018; Buget: 22000 Ron, Director ȘL Dr. Ing. Gabriela Nicolescu

 

 

  • articole în reviste ISI

 

  1. Double-Reinforced Fish Gelatin Composite Scaffolds for Osteochondral Substitutes, AG Toader, GM Vlasceanu, A Serafim, A Banciu, M Ionita, Materials2023, 16(5), 1815; https://doi.org/10.3390/ma16051815
  2. The current state of the art in gellan-based printing inks in tissue engineering, AI Cernencu, M Ioniță, Carbohydrate Polymers, 120676, 2023, https://doi.org/10.1016/j.carbpol.2023.120676
  3. Development of mesoporous borosilicate bioactive glass nanoparticles containing Mg2+ and Zn2+: biocompatibility, bioactivity and antibacterial activity, AI Damian-Buda, G Voicu, BS Vasile, A Banciu, F Iordache, LT Ciocan, Journal of Non-Crystalline Solids 2022, 594, 121819, https://doi.org/10.1016/j.jnoncrysol.2022.121819
  1. Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review, DD Banciu, D Crețoiu, SM Crețoiu, A Banciu, D Popa, R David, International Journal of Molecular Sciences 2022, 23 (13), 7017, DOI: 10.3390/ijms23137017
  1. Graphene toxicity and future perspectives in healthcare and biomedicine, EA Chiticaru, M Ioniţă, FlatChem, 100417, 2022, 3https://doi.org/10.1016/j.flatc.2022.100417
  2. Chitosan-Based Materials Featuring Multiscale Anisotropy for Wider Tissue Engineering Applications, GM Vlăsceanu, M Ioniță, CC Popescu, ED Giol, I Ionescu, 5336, J. Mol. Sci.2022, 23(10), 5336; https://doi.org/10.3390/ijms23105336
  3. Electrochemical detection platform based on RGO functionalized with diazonium salt for DNA hybridization, EA Chiticaru, L Pilan, M Ioniţă, Biosensors 2022, 12(1), 39; https://doi.org/10.3390/bios12010039
  4. Bacterial Cellulose Hybrid Composites with Calcium Phosphate for Bone Tissue Regeneration, C Busuioc, G Isopencu, A Banciu, DD Banciu, O Oprea, A Mocanu, International Journal of Molecular Sciences 2022, 23 (24), 16180, https://doi.org/10.3390/ijms232416180
  5. Exploring inflammatory status in febrile seizures associated with urinary tract infections: a two-step cluster approach, RM Costea, I Maniu, L Dobrota, R Pérez-Elvira, M Agudo, Brain Sciences 2021, 11 (9), 1168, doi: 10.3390/brainsci11091168
  6. Fecal Microbiota Transplant in Severe and Non-Severe Clostridioides difficile Infection. Is There a Role of FMT in Primary Severe CDI?, D Popa, B Neamtu, M Mihalache, A Boicean, A Banciu, DD Banciu, Journal of Clinical Medicine 2021, 10 (24), 5822, doi: 3390/jcm10245822
  7. Development of new Mg-or Sr-containing bioactive interfaces to stimulate osseointegration of metallic implants, SI Jinga, VP Toma, I Constantinoiu, A Banciu, DD Banciu, C Busuioc, Applied Sciences 2020, 10 (19), 6647, https://doi.org/10.3390/app10196647
  8. Mesoporous Bioactive Glass Nanoparticles in the SiO2-P2O5-CaO-MO (M=Mg, Zn) System: Synthesis and Properties, AI Damian-Buda, CD Ghițulică, A Cucuruz, G Voicu, D Culita, … Journal of Functional Biomaterials 2022, 13 (4), 180, doi: 10.3390/jfb13040180
  9. 3D Printed Composite Scaffolds of GelMA and Hydroxyapatite Nanopowders Doped with Mg/Zn Ions to Evaluate the Expression of Genes and Proteins of Osteogenic Markers, R Leu Alexa, A Cucuruz, CD Ghițulică, G Voicu, LR Stamat, S Dinescu, …Nanomaterials 2022 12 (19), 3420, https://doi.org/10.3390/nano12193420
  10. Processing of Calcium Magnesium Silicates by the Sol–Gel Route, AE Alecu, CC Costea, VA Surdu, G Voicu, SI Jinga, C Busuioc, Gels 2022, 8 (9), 574, https://doi.org/10.3390/gels8090574
  11. 3D printable composite biomaterials based on GelMA and hydroxyapatite powders doped with cerium ions for bone tissue regeneration, R Leu Alexa, A Cucuruz, CD Ghițulică, G Voicu, LR Stamat, S Dinescu, …International Journal of Molecular Sciences 2022, 23 (3), 1841, https://doi.org/10.3390/ijms23031841
  12. Synthesis and characterization of ZnO (MgO)-CaO-SiO2-P2O5 bioglass obtained by sol-gel method in presence of surfactant agent, CD Ghiţulică, AI Damian-Buda, A Cucuruz, G Voicu, Gels, 2021, 7 (4), 187, DOI: 3390/gels7040187
  13. Double-Cross-Linked Networks Based on Methacryloyl Mucin, Elena Olăreț, B. Bălănucă, A.M. Onaș, J. Ghițman, H. Iovu, Izabela-Cristina Stancu, Andrada Serafim, Polymers 2021, 13(11), 1706; https://doi.org/10.3390/polym13111706
  14. Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications, Elena Olăreț, Izabela-Cristina Stancu, H. Iovu, A. Serafim, Materials2021, 14(22), 6763; https://doi.org/10.3390/ma14226763
  15. Recent Efforts and Milestones for Simulating Nucleic Acid FRET Experiments through Computational Methods, S Muraru, S Muraru, FR Nitu, M Ionita, Journal of Chemical Information and Modeling 62 (2), 232-239,https://doi.org/10.1021/acs.jcim.1c00957
  16. Graphene–Oxide Porous Biopolymer Hybrids Enhance In Vitro Osteogenic Differentiation and Promote Ectopic Osteogenesis In Vivo, A Șelaru, H Herman, GM Vlăsceanu, S Dinescu, S Gharbia, C Baltă, International Journal of Molecular Sciences 23 (1), 491, doi: 10.3390/ijms23010491
  17. Computational methods towards increased efficiency design of graphene membranes for gas separation and water desalination, S Muraru, M Ionita, Reviews in Chemical Engineering 2020, 38 (1), 77-94, https://doi.org/10.1515/revce-2019-0048
  18. 3D POSS cages decorated 2D graphenic sheets: A versatile platform for silicon-carbonaceous nano-additives design, A Lungu, AI Cernencu, GM Vlasceanu, NM Florea, M Ionita, H Iovu, Composites Part B: Engineering 207, 108578, https://doi.org/10.1016/j.compositesb.2020.108578
  19. Label-free homogeneous microRNA detection in cell culture medium based on graphene oxide and specific fluorescence quenching, FR Nitu, L Savu, S Muraru, I Stoian, M Ionită, Nanomaterials 11 (2), 368, doi: 3390/nano11020368
  20. From Unidimensional Carbonaceous Materials to Multidimensional Structures Through Molecular Modeling, EA Chiticaru, S Muraru, M Ioniţă, Carbon Related Materials: Commemoration for Nobel Laureate Professor Suzuki, DOI: 10.1007/978-981-15-7610-2_1
  21. Towards Performant Design of Carbon-Based Nanomotors for Hydrogen Separation through Molecular Dynamics Simulations, S Muraru, M Ionita, International Journal of Molecular Sciences 21 (24), 9588; https://doi.org/10.3390/ijms21249588
  22. Investigating Hydrogen Separation in a Novel Rotating Carbon Nanotube–Carbon Nanocone Setup Using Molecular Dynamics Simulations, S Muraru, S Muraru, M Ionita, Coatings, 2020, 10 (12), 1207, https://doi.org/10.3390/coatings10121207
  23. Qualifying osteogenic potency assay metrics for human multipotent stromal cells: TGF-β2 a telling eligible biomarker, AM Ofiteru, DF Becheru, S Gharbia, C Balta, H Herman, B Mladin, M Ionita, Cells 9 (12), 2559, doi: 3390/cells9122559
  24. Super carbonaceous graphene-based structure as a gas separation membrane: a non-equilibrium molecular dynamics investigation, S Muraru, M Ionita, Composites Part B: Engineering 196, 108140, https://doi.org/10.1016/j.compositesb.2020.108140
  25. Comprehensive appraisal of graphene–oxide ratio in porous biopolymer hybrids targeting bone-tissue regeneration, GM Vlasceanu, A Șelaru, S Dinescu, C Balta, H Herman, S Gharbia, Nanomaterials, 2020, 10 (8), 1444, doi: 10.3390/nano10081444
  26. GOPY: A tool for building 2D graphene-based computational models, S Muraru, JS Burns, M Ionita, SoftwareX 12, 100586, https://doi.org/10.1016/j.softx.2020.100586
  27. A Molecular Dynamics Study of Small Gas Molecules Diffusion Through Composite Polysulfone/Carbon Nanotube and Polysulfone/Graphene Membranes, S Muraru, M Ionita, Materiale Plastice 2020, 57 (2), 87-93, https://doi.org/10.37358/Mat.Plast.1964
  28. Oligonucleotide Detection and Optical Measurement with Graphene Oxide in the Presence of Bovine Serum Albumin Enabled by Use of Surfactants and Salts, FR Nitu, JS Burns, M Ionită, Coatings2020, 10(4), 420; https://doi.org/10.3390/coatings10040420
  29. Molecular Dynamics Simulations of DNA Adsorption on Graphene Oxide and Reduced Graphene Oxide-PEG-NH2in the Presence of Mg2+ and Cl− ions, S Muraru, CG Samoila, EI Slusanschi, JS Burns, M Ionita, Coatings 2020, 10(3), 289; https://doi.org/10.3390/coatings10030289
  30. Graphene oxide reinforcing genipin crosslinked chitosan-gelatin blend films, GM Vlasceanu, LE Crica, AM Pandele, M Ionita, Coatings2020, 10(2), 189; https://doi.org/10.3390/coatings10020189
  31. Impact of nano-morphology, lattice defects and conductivity on the performance of graphene based electrochemical biosensors, T Tite, EA Chiticaru, JS Burns, M Ioniţă, Journal of nanobiotechnology 2019, 17, 1-22, https://doi.org/10.1186/s12951-019-0535-6
  32. Bioinspired 3D printable pectin-nanocellulose ink formulations, Alexandra I Cernencu, Adriana Lungu, Izabela-Cristina Stancu, Andrada Serafim, Ellinor Heggset, Kristin Syverud, Horia Iovu, Carbohydrate polymers, 2019, 220, 12-21 https://doi.org/10.1016/j.carbpol.2019.05.026
  33. Graphene oxide enhances chitosan-based 3D scaffold properties for bone tissue engineering, S Dinescu, M Ionita, SR Ignat, M Costache, A Hermenean, International journal of molecular sciences 2019, 20 (20), 5077, doi: 3390/ijms20205077
  34. Internal and external surface features of newly developed porous ceramics with random interconnected 3D channels by a fibrous sacrificial porogen method, AC Mocanu, M Miculescu, T Machedon-Pisu, A Maidaniuc, RC Ciocoiu, Applied Surface Science 2019, 489, 226-238, https://doi.org/10.1016/j.apsusc.2019.05.354
  35. Influence of graphene oxide concentration when fabricating an electrochemical biosensor for DNA detection, EA Chiticaru, L Pilan, CM Damian, E Vasile, JS Burns, M Ioniţă, Biosensors 2019, 9 (4), 113, https://doi.org/10.3390/bios9040113
  36. Versatile biomaterial platform enriched with graphene oxide and carbon nanotubes for multiple tissue engineering applications, SR Ignat, AD Lazăr, A Şelaru, I Samoilă, GM Vlăsceanu, M Ioniţă, E Radu, International journal of molecular sciences 2019, 20 (16), 3868, doi: 3390/ijms20163868
  37. Graphene inks for the 3D printing of cell culture scaffolds and related molecular arrays, GM Vlăsceanu, H Iovu, M Ioniţă, Composites Part B: Engineering 2019, 162, 712-723, https://doi.org/10.1016/j.compositesb.2019.01.010
  38. Optical graphene-based biosensor for nucleic acid detection; influence of graphene functionalization and ionic strength, DF Becheru, GM Vlăsceanu, A Banciu, E Vasile, M Ioniţă, JS Burns, International Journal of Molecular Sciences 2018, 19 (10), 3230, https://doi.org/10.3390/ijms19103230
  39. Synergistic effect of carbon nanotubes and graphene for high performance cellulose acetate membranes in biomedical applications, M Ioniță, LE Crică, SI Voicu, S Dinescu, F Miculescu, M Costache, H Iovu, Carbohydrate polymers 183, 50-61, https://doi.org/10.1016/j.carbpol.2017.10.095
  40. Chitosan-graphene oxide 3D scaffolds as promising tools for bone regeneration in critical-size mouse calvarial defects, A Hermenean, A Codreanu, H Herman, C Balta, M Rosu, CV Mihali, Scientific reports 2017, 7 (1), 16641, doi: 10.1038/s41598-017-16599-5
  41. Graphene oxide improves chitosan-based biomaterials with applications in bone tissue engineering, S Dinescu, S Ignat, L Predoiu, A Hermenean, M Ionita, M Mladenov, …, Romanian Biotechnological Letters 22 (6), 13108-13115
  42. Novel Chitosan-poly (vinyl alcohol)/graphene oxide biocomposites 3D porous scaffolds, AM Pandele, M Ionita, L Crica, E Vasile, H Iovu, Composites Part B: Engineering 2017, 126, 81-87, https://doi.org/10.1016/j.compositesb.2017.06.010
  43. Graphene and functionalized graphene: Extraordinary prospects for nanobiocomposite materials, M Ioniţă, GM Vlăsceanu, AA Watzlawek, SI Voicu, JS Burns, H Iovu, Composites Part B: Engineering 2017, 121, 34-57, https://doi.org/10.1016/j.compositesb.2017.03.031
  44. Porous chitosan/graphene oxide biocomposites for tissue engineering, AM Pandele, M Ionita, A Lungu, E Vasile, C Zaharia, H Iovu, Polymer Composites 38 (2), 363-370, https://doi.org/10.1002/pc.23594
  45. Versatile graphene biosensors for enhancing human cell therapy, JS George M.Vlăsceanu Roxana-MariaAmărandi, Mariana Ioniță, TeddyTite, Horia Iovu…, Biosensors and Bioelectronics 2018, 117, 283-302, DOI: 1016/j.bios.2018.04.053
  46. Composite fiber networks based on polycaprolactone and bioactive glass-ceramics for tissue engineering applications, SI Jinga, CC Costea, AI Zamfirescu, A Banciu, DD Banciu, C Busuioc, Polymers, 2020, 12 (8), 1806, https://doi.org/10.3390/polym12081806
  47. Scaffolduri fibroase compozite proiectate pentru regenerare osoasă, AI Zamfirescu, A Banciu, D Banciu, SI Jinga, C Busuioc, Revista Romana de Materiale 50 (2), 101-105
  48. Composite fibrous scaffolds designed for bone regeneration, AI Zamfirescu, A Banciu, D Banciu, SI Jinga, C Busuioc, Revista Romana de Materiale-Romanian Journal of Materials 50 (2), 161-165
  49. RNA-binding proteins HuB, HuC, and HuD are distinctly regulated in dorsal root ganglia neurons from STZ-sensitive compared to STZ-resistant diabetic mice, CC Mustăciosu, A Banciu, CM Rusu, DD Banciu, D Savu, M Radu, … International journal of molecular sciences 20 (8), 1965
  50. Beta-estradiol regulates voltage-gated calcium channels and estrogen receptors in telocytes from human myometrium, A Banciu, DD Banciu, CC Mustaciosu, M Radu, D Cretoiu, J Xiao, N. Suciu, BM Radu, International Journal of Molecular Sciences 2018, 19 (5), 1413, doi: 3390/ijms19051413
  51. Altered inflammation and redox networks in the blood of patients with mild dementia, A Cuadrado, E Milanesi, M Dobre, A Cucos, G Piñol-Ripoll, C Tudose, …Free Radical Biology and Medicine 165, 51
  52. Influence of dopant nature on biological properties of ZnO thin-film coatings on Ti alloy substrate, S Stoleriu, C Lungu, CD Ghitulica, A Surdu, G Voicu, A Cucuruz, …Nanomaterials 2020, 10 (1), 129, doi: 3390/nano10010129
  53. Ceramics based on calcium phosphates substituted with magnesium ions for bone regeneration, CD Ghițulică, A Cucuruz, G Voicu, AT Cucuruz, S Dinescu, A Selaru, …International Journal of Applied Ceramic Technology 17 (1), 342-353, https://doi.org/10.1111/ijac.13333